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Saeb-Parsy Lab

Department of Surgery

Welcome to the Saeb-Parsy Lab Home Page

The Saeb-Parsy lab, in the Department of Surgery, is focused on collaborative, multidisciplinary and translational research in experimental and clinical transplantation. Our experimental research themes are underpinned by a commitment to developing innovative and inclusive multidisciplinary collaborations with academic and industrial partners to address fundamental questions in cellular and organ transplantation and in cancer immunobiology. Our clinical research programme similarly utilises a multidisciplinary approach to address key challenges in organ transplantation.

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Clinical Research Themes

Core Facilities and Recourses

A key aim of the Saeb-Parsy Lab is to create infrastructure and resources to support collaborative research that utilises human tissue or requires the use of in vivo experimental models. This aim is pursued through establishment of two core facilities:

Selected Publications

 

Lawson ARJ, Abascal F, Coorens THH, Hooks Y, O'Neill L, Latimer C, Raine K, Sanders MA, Warren AY, Mahbubani KTA, Bareham B, Butler TM, Harvey LMR, Cagan A, Menzies A, Moore L, Colquhoun AJ, Turner W, Thomas B, Gnanapragasam V, Williams N, Rassl DM, Vöhringer H, Zumalave S, Nangalia J, Tubío JMC, Gerstung M, Saeb-Parsy K, Stratton MR, Campbell PJ, Mitchell TJ, Martincorena I (2020). Extensive heterogeneity in somatic mutation and selection in the human bladder. Science. 2;370(6512):75-82.

Litviňuková M, Talavera-López C, Maatz H, Reichart D, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar O, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA (2020) Cells of the adult human heart. Nature. doi: 10.1038/s41586-020-2797-4.

Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P, Dentro S, Dawson K, Butler T, Rahbari R, Mitchell TJ, Maura F, Nangalia J, Tarpey PS, Brunner SF, Lee-Six H, Hooks Y, Moody S, Mahbubani K, Jimenez-Linan M, Brosens JJ, Lacobuzio-Donahue CA,  Martincorena I, Saeb-Parsy K, Campbell PJ, Stratton MR.  (2020) The mutational landscape of normal human endometrial epithelium. Nature 580(7805):640-646.

James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA. (2020) Distinct microbial and immune niches of the human colon. Nature Immunology. 21(3):343-353.

Coorens THH, Treger TD, Al-Saadi R, Moore L, Tran MGB, Mitchell TJ, Tugnait S, Thevanesan C, Young MD, Oliver TRW, Oostveen M, Collord G, Tarpey PS, Cagan A, Hooks Y, Brougham M, Reynolds BC, Barone G, Anderson J, Jorgensen M, Burke GAA, Visser J, Nicholson JC, Smeulders N, Mushtaq I, Stewart GD, Campbell PJ, Wedge DC, Martincorena I, Rampling D, Hook L, Warren AY, Coleman N, Chowdhury T, Sebire N, Drost J, Saeb-Parsy K, Stratton MR, Straathof K, Pritchard-Jones K, Behjati S. (2019) Embryonal precursors of Wilms tumor. Science. 366(6470):1247-1251

Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K*, Murphy MP* (2019) Succinate accumulation drives ischaemia reperfusion injury during organ transplantation. Nature Metabolism 1;966-974. * Equal contribution

Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O'Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR (2019) The landscape of somatic mutation in normal colorectal epithelial cells. Nature. 574(7779):532-537.

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine. Jul;25(7):1153-1163.

Tysoe OC , Justin AW , Brevini T , Chen SE , Mahbubani KT , Frank AK , Zedira H , Melum E , Saeb-Parsy K*, Markaki* AE , Vallier E*, Sampaziotis F* (2019). Isolation and propagation of primary human cholangiocyte organoids for the generation of bio-engineered biliary tissue. Nature Protocols 14(6):1884-1925. * Equal contribution.

Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH (2018). Somatic mutant clones colonize the human esophagus with age. Science 362(6417):911-917.

Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M (2017). Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine 23(12):1424-1435.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J,  Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander A, Sinha S,  Hannan NRF, Wynn TA, Karlsen TH, MelumE, Markaki AE, Saeb-Parsy K*, Vallier L* (2017). Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23(8):954-963 (* equal contribution).

Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K (2015) Transplanting suboptimum organs: medico-legal implications. Lancet 386: 719-21.

Sampaziotis F, Brito MC, Bertero A, Madrigal P, Saeb-Parsy K, Soares F, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S,  Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology 33: 845-52.

Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431-5.

A full list of publications is available here.