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Saeb-Parsy Lab

Department of Surgery

Studying at Cambridge

 

Publications

Selected Publications - Papers

 

  1. Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones P. Somatic mutant clones colonize the human esophagus with age. Science (2018) In Press. doi: 10.1126/science.aau3879
  2. Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST. Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold. Biomaterials (2018) 182:299-311.
  3. Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discovery (2018) 8(7):850-865.
  4. Martin JL, Gruszczyk AV, Beach TE, Murphy MP, Saeb-Parsy K. Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury. Pediatric Nephrololgy (2018) Jun 2. doi: 10.1007/s00467-018-3984-5. [Epub ahead of print]
  5. Kohlhauer M, Dawkins S, Costa ASH, Lee R, Young T, Pell VR, Choudhury RP, Banning AP, Kharbanda RK; Oxford Acute Myocardial Infarction (OxAMI) Study, Saeb-Parsy K, Murphy MP, Frezza C, Krieg T, Channon KM. Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury. Journal of American Heart Association (2018)7(8). pii: e007546. doi: 10.1161/JAHA.117.007546.
  6. Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Science Translational Medicine (2017) 29;9(418).
  7. Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M (2017). Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine (2017) 23(12):1424-1435.
  8. Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J,  Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander A, Sinha S,  Hannan NRF, Wynn TA, Karlsen TH, MelumE, Markaki4 AE, Saeb-Parsy K*, Vallier L* (2017). Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine (2017) 23(8):954-963 (* equal contribution)
  9. Justin AW, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F. Advances in the generation of bioengineered bile ducts. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2017) In Press.
  10. Hakeem A, Chen J, Iype S, Clatworthy M, Watson C, Godfrey EM, Upponi S, Saeb-Parsy K (2017) Pancreatic Allograft Thrombosis: Suggestion for a CT grading system and management algorithm. American Journal of Transplantation (in press).
  11. Kilbride P, Mahbubani KT, Saeb-Parsy K, Morris GJ (2017) Engaging Cold to Upregulate Cell Proliferation in Alginate-Encapsulated Liver Spheroids. Tissue Engineering Part C Methods 23(8):455-464.
  12. Arndt S, Baeza-Garza CD, Logan A, Rosa T, Wedmann R, Prime TA, Martin JL, Saeb-Parsy K, Krieg T, Filipovic MR, Hartley RC, Murphy MP (2017). Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA. Journal of Biological Chemistry 292(19):7761-7773.
  13. Barlow AD, Saeb-Parsy K, Watson CJ (2017) An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes: a UK Transplant Registry study. Transplant International (in press).
  14. Hosgood SA, Saeb-Parsy K, Wilson C, Callaghan C, Collett D, Nicholson ML (2017) Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation. BMJ Open 7(1):e012237.
  15. Mah TJ, Mallon DH, Brewster O, Saeb-Parsy K, Butler AJ, Bradley JA, Kosmoliaptsis V (2017) Ureteric complications in recipients of kidneys from donation after circulatory death donors. Clinical Transplantation (in press).
  16. Amin I, Butler AJ, Defries G, Russell NK, Harper SJ, Jah A, Saeb-Parsy K, Pettigrew GJ, Watson CJ (2017) A Single-Centre Experience of Roux-en-Y Enteric Drainage for Pancreas Transplantation. Transplant International 30(4):410-419.
  17. Hosgood SA, Saeb-Parsy K, Hamed MO, Nicholson ML (2016) Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion. American Journal of Transplantation 16:3282-3285.
  18. Harper IG, Ali JM, Harper SJ, Wlodek E, Alsughayyir J, Negus MC, Qureshi MS, Motalleb-Zadeh R, Saeb-Parsy K, Bolton EM, Bradley JA, Clatworthy MR, Conlon TM, Pettigrew GJ. (2016) Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant. Cell Reports 15:1214-27.
  19. Ali JM, Negus MC, Conlon TM, Harper IG, Qureshi MS, Motallebzadeh R, Willis R, Saeb-Parsy K, Bolton EM, Bradley JA, Pettigrew GJ (2016) Diversity of the CD4 T cell alloresponse: The short and the long of it. Cell Reports 14:1232-45.
  20. Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Kreig T, Murphy M (2016) A unifying mechanism for mitochondrial superoxide production during ischaemia-reperfusion injury. Cell Metabolism 23: 254-63.
  21. Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K (2015) Transplanting suboptimum organs: medico-legal implications. Lancet 386: 719-21.
  22. Sampaziotis F, Brito MC, Bertero A, Madrigal P, Saeb-Parsy K, Soares F, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S,  Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology 33: 845-52.
  23. Dare A, Logan A, PrimeT, Rogatti S, Goddard M, Bolton E, Bradley JA, Pettigrew GJ, Murphy M, Saeb-Parsy K (2015) The mitochondria-targeted antioxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model. Journal of Heart and Lung Transplantation 34: 1471-80.
  24. Barlow AD, Hamed MO, Mallon DH, Brais RJ, Gribble FM, Scott MA, Howat WJ, Bradley JA, Bolton EM, Pettigrew GJ, Hosgood SA, Nicholson ML, Saeb-Parsy K (2015) Use of ex vivo normothermic perfusion for quality assessment of discarded human donor pancreases. American Journal of Transplantation 15: 2475-82.
  25. Mallon DH, Riddiough GE, Summers DM, Butler AJ, Callaghan CJ, Bradbury L, Saeb-Parsy K, Torpey N, Bradley JA, Pettigrew GJ (2015). Successful transplantation of kidneys from elderly circulatory death donors by using microscopic and macroscopic characteristics to guide single or dual implantation. American Journal of Transplantation 15: 2931-9.
  26. Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431-5.
  27. Dare AJ, Bolton EA, Pettigrew GJ, Bradley JA, Saeb-Parsy K, Murphy MP (2015) Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ. Redox Biology 5:163-168.
  28. Hamed MO, Chen Y, Pasea L, Watson CJ, Torpey N, Bradley JA, Pettigrew GJ, Saeb-Parsy K (2015) Early graft loss after kidney transplantation: risk factors and consequences. American Journal of Transplantation 15:1632-43.
  29. Kosmoliaptsis V, Salji M, Bardsley V, Chen Y, Thiru S, Griffiths MH, Copley HC, Saeb Parsy K, Bradley JA, Torpey N, Pettigrew GJ (2015) Baseline donor chronic renal injury confers the same transplant survival disadvantage for DCD and DBD kidneys. American Journal of Transplantation 15:754-63.
  30. Li J, Kent DG, Godfrey AL, Manning H, Nangalia J, Aziz A, Chen E, Saeb-Parsy K, Fink J, Sneade R, Hamilton T, Pask D, Silber Y, Zhao X, Ghevaert C, Liu P, Green AR (2014). JAK2V617F-homozygosity drives a phenotypic switch between myeloproliferative neoplasms in a murine model, but is insufficient to sustain clonal expansion. Blood 123:3139-51.
  31. Dare A, Pettigrew GJ, Saeb-Parsy K (2014) Pre-operative assessment of the deceased donor kidney: from macroscopic appearance to molecular biomarkers. Transplantation 97:797-807.
  32. Callaghan CJ, Harper SJ, Saeb-Parsy K, Hudson A, Gibbs P, Watson CJ, Praseedom RK, Butler AJ, Pettigrew GJ, Bradley JA (2014). The discard of deceased donor kidneys in UK. Clinical Transplantation 28:345-53.
  33. Chubra M, Conlon T, Saeb-Parsy K, Pettigrew GJ (2013) BAFF and associated TNF superfamily members in renal transplantation: an end to Blysful ignorance. Transplantation (in press).
  34. Sivaganesh S, Harper SJ, Conlon TM, Saeb-Parsy K, Negus MC, Motallebzadeh R, Bolton EM, Bradley JA, Pettigrew GJ (2013) Co-presentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells. Journal of Immunology 190:5829-38.
  35. Conlon T, Cole J, Motallebzadeh J, Harper I, Callaghan C, Bolton E, Bradley JA, Saeb-Parsy K, Pettigrew GJ (2012) Unlinked memory helper responses promote long-lasting humoral alloimmunity. Journal of Immunology 189:5703-12.
  36. Conlon TM, Saeb-Parsy K, Cole JL, Motallebzadeh R, Qureshi MS, Rehakova S, Negus MC, Callaghan CJ, Bolton EM, Bradley JA, Pettigrew GJ (2012). Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. Journal of Immunology 15, 2643-52.
  37. Saeb-Parsy K & Watson CJ (2011) Kidney Transplantation: Surgical Aspects. Medicine 39, 443-7.
  38. Saeb-Parsy K, Kosmoliaptsis V, Sharples LD, Watson CJ, Clatworthy MR, Taylor CJ, Pettigrew GJ, Bradley JA (2010) Donor Type Does Not Influence the Incidence of Major Urologic Complications After Kidney Transplantation. Transplantation 90, 1085-90.
  39. Saeb-Parsy K, Mills A, Rang C, Reed JB, Harris AM (2010). Emergency laparoscopic cholecystectomy in an unselected cohort: A safe and viable option in a specialist centre. International Journal of Surgery 8, 489-93.
  40. Bhumbra GS, Lombardelli S, Gonzalez JA, Saeb-Parsy K and Dyball REJ (2009). Daily Rhythms of Spike Coding in the Rat Supraoptic Nucleus. Journal of Neuroendocrinology 21, 935-945.
  41. Win TS, Rehakova S, Negus M, Saeb-Parsy K, Goddard M, Conlon M, Bolton EM, Bradley JA & Pettigrew GJ (2009) Donor CD4 T cells contribute to cardiac allograft vasculopathy by providing help for autoantibody production. Circulation: Heart Failure 2, 361-9.
  42. Saeb-Parsy K, Jah A, Butler AJ, Large S, Pettigrew GJ, Praseedom RK, Watson CJ & Jamieson NV (2009) Use of a donor aortic interposition allograft to treat stenosis of the suprahepatic inferior vena cava after liver transplantation. Liver Transplantation 15, 662-5.
  43. Drain AJ, Saeb-Parsy K, Shah AK & Rassl D and AJ Ritchie (2006) Mesothelioma with non-pleural malignancy: a red herring or just an uncommon pairing? Journal of Cardiothoracic Surgery 1, 39.
  44. Saeb-Parsy K, Athanassoglou V & JR Benson (2006) Talc seromadesis: A novel technique for the treatment of chronic seromas following breast surgery. Breast Journal 12, 502-4.
  45. Benson JR, Saeb-Parsy K (2006) Meta-analyses in cancer clinical trials: principles and pitfalls. World Journal of Surgery 30, 1177-83.
  46. Saeb-Parsy K, Omer A, Hall NR (2006) Melaena as the presenting symptom of gastric mucosal injury due to blunt abdominal trauma. Emergency Medicine Journal 23, 34.
  47. Saeb-Parsy K, Routledge T & Ritchie AJ (2005) The use of vacuum-assisted closure in the treatment of post-transplant wound infections. Journal of Heart and Lung Transplantation 24, 1444.
  48. Bhumbra GS, Inyushkin AN, Saeb-Parsy K, Hon A & Dyball REJ (2005) Rhythmic changes in spike coding in the rat suprachiasmatic nucleus. Journal of Physiology 563, 291-307.
  49. Saeb-Parsy K & Dyball REJ (2004) Responses of cells in the rat supraoptic nucleus in vivo to stimulation of afferent pathways are different at different times of the light/dark cycle. Journal of Neuroendocrinology 16, 131-137.
  50. Saeb-Parsy K & Dyball REJ (2003) Responses of cells in the rat suprachiasmatic nucleus in vivo to stimulation of afferent pathways are different at different times of the light/dark cycle. Journal of Neuroendocrinology 15, 895-903.
  51. Saeb-Parsy K & Dyball REJ (2003) Defined cell groups in the rat suprachiasmatic nucleus have different day/night rhythms of single-unit activity in vivo. Journal of Biological Rhythms 18, 26-42.
  52. Saeb-Parsy K, Lombardelli S, Khan FZ, McDowall K, Au-Yong I and Dyball REJ (2000) Neural connections of hypothalamic neuroendocrine nuclei in the rat. Journal of Neuroendocrinology 12, 635-648.
  53. Cui L-N, Saeb-Parsy K & Dyball REJ (1997) Neurones in the supraoptic nucleus of the rat are regulated by a projection from the suprachiasmatic nucleus. Journal of Physiology 502, 149-159.

 

Selected Publications - Textbooks

1.    Essential Surgery (5th Ed). Quick CRG, Reed JR, Saeb-Parsy K & Harper S. Churchill Livingstone, 2013, 688 pp, ISBN 0702046744.

2.    Instant Pharmacology. Saeb-Parsy K, Assomull RG, Kelly E, Khan FZ & Saeb-Parsy K. John Wiley & Sons Ltd, 1999, 368 pp, ISBN: 0471976393.