Our experimental research programme is focused on transplantation of cells, bioengineered tissues, organs and tumours in three main themes. Our overall aim is to study the function and immunogenicity of fresh and cryopreserved transplanted cells and tissues, to ameliorate the immune response and ischaemia-reperfusion injury after transplantation, and to study safety and efficacy of cancer immunotherapies. Our programme makes extensive use of immunodeficient and immune-reconstituted humanised mice and mouse, pig and human models of ischaemia-reperfusion injury.
