Safety and Efficacy of Cancer Immunotherapies in Humanised Mice

Investigation of Safety and Efficacy of Cancer Immunotherapies using Humanised Mouse Models

Immunodeficient mice reconstituted with the human immune compartment, or humanised mice, represent a potentially powerful model to study human cancer biology, as well as the safety and efficacy of cancer immunotherapies. We are applying our humanised mouse platform, in collaboration with Prof Richard Stebbings at Medimmune to investigate human cancer immunotherapies. This programme involves collaborations with Dr Merixell Huch from the Gurdon Institute and Prof Ludovic Vallier from the Cambridge Stem Cell Institute to use human tumour organoids, or tumoroids, transplanted in humanised mice as a more advanced and representative model to study human cancer biology and immunotherapy.

 tumoroid.png

Key Related Publications

  • Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M (2017). Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine Dec;23(12):1424-1435.

  • Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones P. Somatic mutant clones colonize the human esophagus with age. Science (2018) In Press. doi: 10.1126/science.aau3879.

  • Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discovery (2018) 8(7):850-865.