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Saeb-Parsy Lab

Department of Surgery

Studying at Cambridge

Welcome to the Saeb-Parsy Lab Website

Welcome to the Saeb-Parsy Lab Home Page

The Saeb-Parsy lab, in the Department of Surgery, is focused on collaborative, multidisciplinary and translational research in experimental and clinical transplantation. Our experimental research themes are underpinned by a commitment to developing innovative and inclusive multidisciplinary collaborations with academic and industrial partners to address fundamental questions in cellular and organ transplantation and in cancer immunobiology. Our clinical research programme similarly utilises a multidisciplinary approach to address key challenges in organ transplantation.

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Clinical Research Themes

Core Facilities and Recourses

A key aim of the Saeb-Parsy Lab is to create infrastructure and resources to support collaborative research that utilises human tissue or requires the use of in vivo experimental models. This aim is pursued through establishment of two core facilities:

Selected Publications

Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones P. Somatic mutant clones colonize the human esophagus with age. Science (2018) In Press. doi: 10.1126/science.aau3879

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J,  Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander A, Sinha S,  Hannan NRF, Wynn TA, Karlsen TH, MelumE, Markaki AE, Saeb-Parsy K*, Vallier L*. Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine (2017) 23(8):954-963 (* equal contribution).

Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M. Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine (2017) 23(12):1424-1435.

Sampaziotis F, Brito MC, Bertero A, Madrigal P, Saeb-Parsy K, Soares F, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S,  Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology 33: 845-52.

Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K. Transplanting suboptimum organs: medico-legal implications. Lancet (2015) 386: 719-21.

Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature (2014) 515(7527):431-5.

A full list of publications is available here.